Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
Identifieur interne : 000105 ( Main/Exploration ); précédent : 000104; suivant : 000106Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
Auteurs : C. E. Van De Sandt [Pays-Bas] ; E. B. Clemens ; E. J. Grant ; L. C. Rowntree ; S. Sant ; H. Halim ; J. Crowe ; A. C. Cheng ; T. C. Kotsimbos ; M. Richards ; A. Miller ; S. Y. C. Tong ; J. Rossjohn ; T. H. O. Nguyen ; S. Gras ; W. Chen ; K. KedzierskaSource :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8+ T cells to mount robust responses. We elucidate the HLA-A*68:01+CD8+ T cell response directed toward an extended influenza-derived nucleoprotein (NP) peptide and show that only ~35% individuals have immunodominant A68/NP145+CD8+ T cell responses. Dissecting A68/NP145+CD8+ T cells in low vs. medium/high responders reveals that high responding donors have A68/NP145+CD8+ memory T cells with clonally expanded TCRαβs, while low-responders display A68/NP145+CD8+ T cells with predominantly naïve phenotypes and non-expanded TCRαβs. Single-cell index sorting and TCRαβ analyses link expansion of A68/NP145+CD8+ T cells to their memory potential. Our study demonstrates the immunodominance potential of influenza-specific CD8+ T cells presented by a risk HLA-A*68:01 molecule and advocates for priming CD8+ T cell compartments in HLA-A*68:01-expressing individuals for establishment of pre-existing protective memory T cell pools.
Url:
DOI: 10.1038/s41467-019-13346-4
PubMed: 31811120
PubMed Central: 6898063
Affiliations:
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E." last="Van De Sandt">C. E. Van De Sandt</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000000084992262</institution-id><institution-id institution-id-type="GRID">grid.7177.6</institution-id><institution>Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC,</institution><institution>University of Amsterdam,</institution></institution-wrap>1066CX Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1066CX Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Clemens, E B" sort="Clemens, E B" uniqKey="Clemens E" first="E. B." last="Clemens">E. B. Clemens</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Grant, E J" sort="Grant, E J" uniqKey="Grant E" first="E. J." last="Grant">E. J. Grant</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Present Address: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Infection and Immunity Program,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC 3800 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3800 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Rowntree, L C" sort="Rowntree, L C" uniqKey="Rowntree L" first="L. C." last="Rowntree">L. C. Rowntree</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Sant, S" sort="Sant, S" uniqKey="Sant S" first="S." last="Sant">S. Sant</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Halim, H" sort="Halim, H" uniqKey="Halim H" first="H." last="Halim">H. Halim</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC 3800 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3800 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Crowe, J" sort="Crowe, J" uniqKey="Crowe J" first="J." last="Crowe">J. Crowe</name><affiliation><nlm:aff id="Aff4">Deepdene Surgery, Deepdene, VIC 3103 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3103 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, A C" sort="Cheng, A C" uniqKey="Cheng A" first="A. C." last="Cheng">A. C. Cheng</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>School of Public Health and Preventive Medicine,</institution><institution>Monash University,</institution></institution-wrap>Melbourne, VIC 3004 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3004 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0432 5259</institution-id><institution-id institution-id-type="GRID">grid.267362.4</institution-id><institution>Infection Prevention and Healthcare Epidemiology Unit, Alfred Health,</institution></institution-wrap>Melbourne, VIC 3004 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kotsimbos, T C" sort="Kotsimbos, T C" uniqKey="Kotsimbos T" first="T. C." last="Kotsimbos">T. C. Kotsimbos</name><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0432 511X</institution-id><institution-id institution-id-type="GRID">grid.1623.6</institution-id><institution>Department of Allergy,</institution><institution>Immunology and Respiratory Medicine, The Alfred Hospital,</institution></institution-wrap>Melbourne, VIC 3004 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3004 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Department of Medicine,</institution><institution>Monash University, Central Clinical School, The Alfred Hospital,</institution></institution-wrap>Melbourne, VIC 3004 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3004 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Richards, M" sort="Richards, M" uniqKey="Richards M" first="M." last="Richards">M. Richards</name><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0624 1200</institution-id><institution-id institution-id-type="GRID">grid.416153.4</institution-id><institution>Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity,</institution></institution-wrap>Parkville, VIC 3050 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3050 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Miller, A" sort="Miller, A" uniqKey="Miller A" first="A." last="Miller">A. Miller</name><affiliation><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0437 5432</institution-id><institution-id institution-id-type="GRID">grid.1022.1</institution-id><institution>Indigenous Research Network,</institution><institution>Griffith University,</institution></institution-wrap>Brisbane, QLD 4222 Australia</nlm:aff><wicri:noCountry code="subfield">QLD 4222 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff16"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2193 0854</institution-id><institution-id institution-id-type="GRID">grid.1023.0</institution-id><institution>Present Address: Office of Indigenous Engagement,</institution><institution>CQUniversity,</institution></institution-wrap>Townsvillle, QLD Australia</nlm:aff><wicri:noCountry code="subfield">QLD Australia</wicri:noCountry></affiliation></author><author><name sortKey="Tong, S Y C" sort="Tong, S Y C" uniqKey="Tong S" first="S. Y. C." last="Tong">S. Y. C. Tong</name><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0624 1200</institution-id><institution-id institution-id-type="GRID">grid.416153.4</institution-id><institution>Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity,</institution></institution-wrap>Parkville, VIC 3050 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3050 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2157 559X</institution-id><institution-id institution-id-type="GRID">grid.1043.6</institution-id><institution>Menzies School of Health Research,</institution><institution>Charles Darwin University,</institution></institution-wrap>Darwin, NT 0811 Australia</nlm:aff><wicri:noCountry code="subfield">NT 0811 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Rossjohn, J" sort="Rossjohn, J" uniqKey="Rossjohn J" first="J." last="Rossjohn">J. Rossjohn</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC 3800 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3800 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Australian Research Council Centre of Excellence for Advanced Molecular Imaging,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC Australia</nlm:aff><wicri:noCountry code="subfield">VIC Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0807 5670</institution-id><institution-id institution-id-type="GRID">grid.5600.3</institution-id><institution>Institute of Infection and Immunity,</institution><institution>Cardiff University School of Medicine,</institution></institution-wrap>Heath Park, Cardiff, CF14 4XN United Kingdom</nlm:aff><wicri:noCountry code="subfield">CF14 4XN United Kingdom</wicri:noCountry></affiliation></author><author><name sortKey="Nguyen, T H O" sort="Nguyen, T H O" uniqKey="Nguyen T" first="T. H. O." last="Nguyen">T. H. O. Nguyen</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gras, S" sort="Gras, S" uniqKey="Gras S" first="S." last="Gras">S. Gras</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC 3800 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3800 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id><institution-id institution-id-type="GRID">grid.1002.3</institution-id><institution>Australian Research Council Centre of Excellence for Advanced Molecular Imaging,</institution><institution>Monash University,</institution></institution-wrap>Clayton, VIC Australia</nlm:aff><wicri:noCountry code="subfield">VIC Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W." last="Chen">W. Chen</name><affiliation><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2342 0938</institution-id><institution-id institution-id-type="GRID">grid.1018.8</institution-id><institution>Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science,</institution><institution>La Trobe University,</institution></institution-wrap>Bundoora, VIC 3086 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3086 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kedzierska, K" sort="Kedzierska, K" uniqKey="Kedzierska K" first="K." last="Kedzierska">K. Kedzierska</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id><institution-id institution-id-type="GRID">grid.1008.9</institution-id><institution>Department of Microbiology and Immunology,</institution><institution> University of Melbourne at The Peter Doherty Institute,</institution></institution-wrap>Melbourne, VIC 3000 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3000 Australia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8<sup>+</sup> T cells to mount robust responses. We elucidate the HLA-A*68:01<sup>+</sup>CD8<sup>+</sup> T cell response directed toward an extended influenza-derived nucleoprotein (NP) peptide and show that only ~35% individuals have immunodominant A68/NP<sub>145</sub><sup>+</sup>CD8<sup>+</sup> T cell responses. Dissecting A68/NP<sub>145</sub><sup>+</sup>CD8<sup>+</sup> T cells in low vs. medium/high responders reveals that high responding donors have A68/NP<sub>145</sub><sup>+</sup>CD8<sup>+</sup> memory T cells with clonally expanded TCRαβs, while low-responders display A68/NP<sub>145</sub><sup>+</sup>CD8<sup>+</sup> T cells with predominantly naïve phenotypes and non-expanded TCRαβs. Single-cell index sorting and TCRαβ analyses link expansion of A68/NP<sub>145</sub><sup>+</sup>CD8<sup>+</sup> T cells to their memory potential. Our study demonstrates the immunodominance potential of influenza-specific CD8<sup>+</sup> T cells presented by a risk HLA-A*68:01 molecule and advocates for priming CD8<sup>+</sup> T cell compartments in HLA-A*68:01-expressing individuals for establishment of pre-existing protective memory T cell pools.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Short, Kr" uniqKey="Short K">KR Short</name></author><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Van De Sandt, Ce" uniqKey="Van De Sandt C">CE van de Sandt</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koutsakos, Marios" uniqKey="Koutsakos M">Marios Koutsakos</name></author><author><name sortKey="Wheatley, Adam K" uniqKey="Wheatley A">Adam K. Wheatley</name></author><author><name sortKey="Loh, Liyen" uniqKey="Loh L">Liyen Loh</name></author><author><name sortKey="Clemens, E Bridie" uniqKey="Clemens E">E. Bridie Clemens</name></author><author><name sortKey="Sant, Sneha" uniqKey="Sant S">Sneha Sant</name></author><author><name sortKey="Nussing, Simone" uniqKey="Nussing S">Simone Nüssing</name></author><author><name sortKey="Fox, Annette" uniqKey="Fox A">Annette Fox</name></author><author><name sortKey="Chung, Amy W" uniqKey="Chung A">Amy W. Chung</name></author><author><name sortKey="Laurie, Karen L" uniqKey="Laurie K">Karen L. Laurie</name></author><author><name sortKey="Hurt, Aeron C" uniqKey="Hurt A">Aeron C. Hurt</name></author><author><name sortKey="Rockman, Steve" uniqKey="Rockman S">Steve Rockman</name></author><author><name sortKey="Lappas, Martha" uniqKey="Lappas M">Martha Lappas</name></author><author><name sortKey="Loudovaris, Thomas" uniqKey="Loudovaris T">Thomas Loudovaris</name></author><author><name sortKey="Mannering, Stuart I" uniqKey="Mannering S">Stuart I. Mannering</name></author><author><name sortKey="Westall, Glen P" uniqKey="Westall G">Glen P. Westall</name></author><author><name sortKey="Elliot, Michael" uniqKey="Elliot M">Michael Elliot</name></author><author><name sortKey="Tangye, Stuart G" uniqKey="Tangye S">Stuart G. Tangye</name></author><author><name sortKey="Wakim, Linda M" uniqKey="Wakim L">Linda M. Wakim</name></author><author><name sortKey="Kent, Stephen J" uniqKey="Kent S">Stephen J. Kent</name></author><author><name sortKey="Nguyen, Thi H O" uniqKey="Nguyen T">Thi H. O. Nguyen</name></author><author><name sortKey="Kedzierska, Katherine" uniqKey="Kedzierska K">Katherine Kedzierska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemens, E" uniqKey="Clemens E">E. Clemens</name></author><author><name sortKey="Van De Sandt, Carolien" uniqKey="Van De Sandt C">Carolien van de Sandt</name></author><author><name sortKey="Wong, Sook" uniqKey="Wong S">Sook Wong</name></author><author><name sortKey="Wakim, Linda" uniqKey="Wakim L">Linda Wakim</name></author><author><name sortKey="Valkenburg, Sophie" uniqKey="Valkenburg S">Sophie Valkenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Sandt, Ce" uniqKey="Van De Sandt C">CE van de Sandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Sandt, Ce" uniqKey="Van De Sandt C">CE van de Sandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinones Parra, S" uniqKey="Quinones Parra S">S Quinones-Parra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Ej" uniqKey="Grant E">EJ Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koutsakos, M" uniqKey="Koutsakos M">M Koutsakos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S Sridhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Sandt, Ce" uniqKey="Van De Sandt C">CE van de Sandt</name></author><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falfan Valencia, R" uniqKey="Falfan Valencia R">R Falfan-Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hertz, T" uniqKey="Hertz T">T Hertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, E" uniqKey="Grant E">E Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Josephs, Tm" uniqKey="Josephs T">TM Josephs</name></author><author><name sortKey="Grant, Ej" uniqKey="Grant E">EJ Grant</name></author><author><name sortKey="Gras, S" uniqKey="Gras S">S Gras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burrows, Sr" uniqKey="Burrows S">SR Burrows</name></author><author><name sortKey="Rossjohn, J" uniqKey="Rossjohn J">J Rossjohn</name></author><author><name sortKey="Mccluskey, J" uniqKey="Mccluskey J">J McCluskey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pymm, P" uniqKey="Pymm P">P Pymm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillaume, P" uniqKey="Guillaume P">P Guillaume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tynan, Fe" uniqKey="Tynan F">FE Tynan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tynan, Fe" uniqKey="Tynan F">FE Tynan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, Rm" uniqKey="Brennan R">RM Brennan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wynn, Kk" uniqKey="Wynn K">KK Wynn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tynan, Fe" uniqKey="Tynan F">FE Tynan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miles, Jj" uniqKey="Miles J">JJ Miles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillespie, Gm" uniqKey="Gillespie G">GM Gillespie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miles, Jj" uniqKey="Miles J">JJ Miles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Probst Kepper, M" uniqKey="Probst Kepper M">M Probst-Kepper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Speir, Ja" uniqKey="Speir J">JA Speir</name></author><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name></author><author><name sortKey="Joly, E" uniqKey="Joly E">E Joly</name></author><author><name sortKey="Butcher, Gw" uniqKey="Butcher G">GW Butcher</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Xg" uniqKey="Yu X">XG Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gras, S" uniqKey="Gras S">S Gras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berkhoff, Eg" uniqKey="Berkhoff E">EG Berkhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berkhoff, Eg" uniqKey="Berkhoff E">EG Berkhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valkenburg, Sa" uniqKey="Valkenburg S">SA Valkenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alanio, C" uniqKey="Alanio C">C Alanio</name></author><author><name sortKey="Lemaitre, F" uniqKey="Lemaitre F">F Lemaitre</name></author><author><name sortKey="Law, Hk" uniqKey="Law H">HK Law</name></author><author><name sortKey="Hasan, M" uniqKey="Hasan M">M Hasan</name></author><author><name sortKey="Albert, Ml" uniqKey="Albert M">ML Albert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Gc" uniqKey="Wang G">GC Wang</name></author><author><name sortKey="Dash, P" uniqKey="Dash P">P Dash</name></author><author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author><author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerundolo, V" uniqKey="Cerundolo V">V Cerundolo</name></author><author><name sortKey="Tse, Ag" uniqKey="Tse A">AG Tse</name></author><author><name sortKey="Salter, Rd" uniqKey="Salter R">RD Salter</name></author><author><name sortKey="Parham, P" uniqKey="Parham P">P Parham</name></author><author><name sortKey="Townsend, A" uniqKey="Townsend A">A Townsend</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodewes, R" uniqKey="Bodewes R">R Bodewes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kucharski, Aj" uniqKey="Kucharski A">AJ Kucharski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gog, Jr" uniqKey="Gog J">JR Gog</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Grenfell, Bt" uniqKey="Grenfell B">BT Grenfell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Hc" uniqKey="Guo H">HC Guo</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hutchinson, Sl" uniqKey="Hutchinson S">SL Hutchinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostick, E" uniqKey="Gostick E">E Gostick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemens, Eb" uniqKey="Clemens E">EB Clemens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aragao, D" uniqKey="Aragao D">D Aragao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabsch, W" uniqKey="Kabsch W">W Kabsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, P" uniqKey="Evans P">P Evans</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Niu, L" uniqKey="Niu L">L Niu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vonrhein, C" uniqKey="Vonrhein C">C Vonrhein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emsley, P" uniqKey="Emsley P">P Emsley</name></author><author><name sortKey="Lohkamp, B" uniqKey="Lohkamp B">B Lohkamp</name></author><author><name sortKey="Scott, Wg" uniqKey="Scott W">WG Scott</name></author><author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K Cowtan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gras, S" uniqKey="Gras S">S Gras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Ej" uniqKey="Grant E">EJ Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dash, P" uniqKey="Dash P">P Dash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krzywinski, M" uniqKey="Krzywinski M">M Krzywinski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W." last="Chen">W. Chen</name><name sortKey="Cheng, A C" sort="Cheng, A C" uniqKey="Cheng A" first="A. C." last="Cheng">A. C. Cheng</name><name sortKey="Clemens, E B" sort="Clemens, E B" uniqKey="Clemens E" first="E. B." last="Clemens">E. B. Clemens</name><name sortKey="Crowe, J" sort="Crowe, J" uniqKey="Crowe J" first="J." last="Crowe">J. Crowe</name><name sortKey="Grant, E J" sort="Grant, E J" uniqKey="Grant E" first="E. J." last="Grant">E. J. Grant</name><name sortKey="Gras, S" sort="Gras, S" uniqKey="Gras S" first="S." last="Gras">S. Gras</name><name sortKey="Halim, H" sort="Halim, H" uniqKey="Halim H" first="H." last="Halim">H. Halim</name><name sortKey="Kedzierska, K" sort="Kedzierska, K" uniqKey="Kedzierska K" first="K." last="Kedzierska">K. Kedzierska</name><name sortKey="Kotsimbos, T C" sort="Kotsimbos, T C" uniqKey="Kotsimbos T" first="T. C." last="Kotsimbos">T. C. Kotsimbos</name><name sortKey="Miller, A" sort="Miller, A" uniqKey="Miller A" first="A." last="Miller">A. Miller</name><name sortKey="Nguyen, T H O" sort="Nguyen, T H O" uniqKey="Nguyen T" first="T. H. O." last="Nguyen">T. H. O. Nguyen</name><name sortKey="Richards, M" sort="Richards, M" uniqKey="Richards M" first="M." last="Richards">M. Richards</name><name sortKey="Rossjohn, J" sort="Rossjohn, J" uniqKey="Rossjohn J" first="J." last="Rossjohn">J. Rossjohn</name><name sortKey="Rowntree, L C" sort="Rowntree, L C" uniqKey="Rowntree L" first="L. C." last="Rowntree">L. C. Rowntree</name><name sortKey="Sant, S" sort="Sant, S" uniqKey="Sant S" first="S." last="Sant">S. Sant</name><name sortKey="Tong, S Y C" sort="Tong, S Y C" uniqKey="Tong S" first="S. Y. C." last="Tong">S. Y. C. Tong</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Van De Sandt, C E" sort="Van De Sandt, C E" uniqKey="Van De Sandt C" first="C. E." last="Van De Sandt">C. E. Van De Sandt</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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